Discovery of Molecule’s Role May Lead to a Diabetes Cure

Discovery of Molecule’s Role May Lead to a Diabetes Cure


Michael Downes: We discovered the physiological
role of FGF1. What we found is that FGF1 when injected into the bloodstream has a potent
glucose lowering ability. Ron Evans: One of the remarkable observations
that we made is that FGF1 is a new regulator of glucose. We did not know that, and it came
out as a surprise. So it’s taking the entire field by surprise, yet at the same time gives
us a very powerful new means to control glucose in the body. Jae Myoung Suh: Instead of looking at growth
and development, which was the historical aspect of this molecule, we decided to look
at this and how it works in metabolism and physiology and ultimately to see if we could
find any links to disease. And what we found is when we administer this molecule to mice
that are diabetic, it was able to very rapidly and sustainably lower the blood glucose, showing
promise of correcting the diabetic phenotype in the mice. Michael Downes: There are more and more type
2 diabetes patients. However, the current treatments that we have are not very efficient
in maintaining normal glucose levels. Whereas what our molecule does is restore insulin’s
ability, which is a whole body system. And in fact, if we injected it directly into the
bloodstream, rather than maybe a subcu. injection, it could actually lower glucose for about
a seven day period, and that is remarkable and unheard of. Maryam Ahmadian: It was very surprising because
FGF1 typically isn’t found circulating in the blood, and the fact that we are able to
inject it and it had such a dramatic effect on blood glucose levels and insulin sensitization
was very surprising. Jae Myoung Suh: At current, we don’t know
the exact details of how FGF1 works to have this quite amazing anti-diabetic property
in mice models, but we are very keen on following up on trying to find out what the underlying
mechanisms are, what are the other players involved. And again, all these new findings
may lead to new targets and new approaches to try to treat diabetes. Ron Evans: I expect that while we’re the initiator
of the discovery, that many labs and many pharmaceutical companies will quickly jump
on this observation because it has a great potential to provide an entirely new type
of therapy to glucose management. In a world of ever more diabetics, this becomes even
more powerful and interesting, and wait for the science but what it can actually do for
people.

7 Replies to “Discovery of Molecule’s Role May Lead to a Diabetes Cure”

  1. My first thought is a celebration feeling –  "BRAVO". My second thought and feeling is, wondering if  can I buy this at Rite-aid tomorrow?  Thanks you, folks.

  2. From my understanding, this has only been tested on mice. If the testing is successful on humans, you guys definitely deserve the Nobel Prize, and your organization is in fact more deserving of that prize than most Nobel Laureates because there have been very few discoveries, for which the Nobel Prize has been awarded, that would effect as many people as a cure for diabetes. My only question is, given the massive amount of profit that pharmaceutical companies and the medical industry makes on the mere treatment of a sustained diabetic condition in a patient, would they ever want a cure to flourish? I know that sounds very cynical, but when we are talking about billions of dollars more in potential revenue from just treating the disease, as opposed to curing it, there is a great incentive for such industries to put up as many road blocks as possible to a cure being released to the public.  

  3. It can be possible to stop diabetes once and for all and holistically implementing science based treatment method in less than within 3 weeks

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