MTHFR, B Vitamin Toxicity and Neuropathy

MTHFR, B Vitamin Toxicity and Neuropathy

okay so we are live I am just waiting
for dr. Thomas to join in we’re really excited to launch your genetic-type we
are going to be talking about specific health conditions as they relate to
methylation and genetic testing and MTHFR we had finished recently a amazing
breakthrough course called MTHFR crash course and now we are launching a new
genetic type and we are going to be doing facebook lives every week and
today we wanted to talk to you about vitamin B toxicity and how it relates to
nerve damage how it relates to MTHFR and how it relates specifically to you so so
we’re really excited to launch this and and really help you and and we’re all so
excited to launch your genetic-type we’re gonna be talking a lot about that
and as we get started here I see dr. Thomas doing my friend can you hear me
John it’s just hopefully your audios working
or my audios working can you hear me looks like your
microphones not plugged in for some reason so I I don’t see a microphone
availability when you join and it should be like a little got it like there you
go all right first time lot going on all right so I was just doing an
introduction we’re excited to be talking we’re going to be doing Facebook lives
once a week and getting starting to build this your genetic-type Facebook
page and hopefully soon to be a very Rea audience in terms of the information
we’re giving John so today we wanted to talk about the mth of again most people
know about that we just finished as we talked about a
crash course on MTHFR and we’re launching your genetic type I’ve wanna
start to make specific topics about things that people are dealing with as
it relates to MTHFR and vitamin B toxicity nerve damage is something that
really is relevant for people so let’s let’s dive into that and come up with
sort of a explanation of why when where what how all those things and explain
your experience and most importantly strategies to recover from this yeah so
you know neuropathy aspects or I know something that both you and I have seen
our practice for you know quite a while and you know people sometimes come in
with the usual suspects we’re talking about neuropathy components that you
know they’re diabetic or they’ve taken a statin drug you know post chemo
components but the problem lies where if somebody has neuropathy symptoms they go
to their neurologist and there’s not the usual suspect as a trigger
they basically can’t you they prepped it basically giving garbage-can diagnosis
of you know some type of video Pathak polyneuropathy or chronic inflammatory
neuropathy basically saying hey you’ve got this but we have no clue why and
that’s where it’s time to start thinking outside the box and a lot of times what
happens is through lab or components or you know through further investigative
components people start realizing they’re trying to connect the dots a
little bit that there is a connection with certainty vitamin components that
are in excess or or toxic to the body that can be factors that drive the
neuropathy symptoms and that’s what we’ll talk about today is kind of the
mechanisms with that how genetic factors play into that because a lot of times
you know if it’s not the usual suspects driving neuropathy these factors from a
b vitamin utilization standpoint and genetic factors such as in th FR NOS s
D components things that nature will talk about a little bit today our big
factors that sometimes are underlying issues of why somebody’s developing
those neuropathy symptoms yeah I know absolutely and I agree with you so they
go to their neurologist they have these weird sensations in their feet or their
hands they’re not really feeling it it’s either their numb its tingly it’s
painful they have a foot drop or they just don’t they feel like there’s
walking on on an surtax and and so that starts the process John so let’s just
fast forward and fast forward to okay I know that there’s a genetic component I
know that there’s this thing that you can do you can do a genetic test and
hopefully they’ve done a complete panel right they’ve done not just the MTHFR
but let’s gonna start from there so how when they’re not getting the answers and
they’re taking like medications and neurontin and gabapentin or they’re
taking other things or even like a B vitamin and they’re getting injections
let’s kind of take it from from the 30,000 view feet and bring it in into
you know the mirror in front of their face yeah so you know when you’re
talking about the genetic connection and the B vitamin excess that can be a
driving factor and so you see this a lot where you know somebody goes to their
their neurologist their primary they have some zurafa the– they run blood
work their b12 levels are high their b6 levels are high b12 and b6 so usually
when you’re talking on neuropathy or the usual suspects that can play into that
we know that b6 toxicity and really when we say b6 toxicity what it really means
is too much of the inactive form of b6 and really to kind of keep this as
implicit expose we hear really technical in biochemistry and neurology aspects
with this but realistically we’re talking about the toxicity aspect with
the vitamins it comes down to how much is outside the cell versus how much can
get inside the cell and that’s sometimes where genetic factors can play in as
well because a lot of times when you’re running bloodwork to look at serum b6
levels or you’re looking at serum b12 levels a lot of times it’s measuring how
much b12 is in the body how much b12 is outside the cells hanging around and if
you see those levels higher or all that’s telling you is that hey you got a
whole bunch to be sexier you got a whole bunch of
beats well that is there but it’s not being utilized properly it’s inactive
it’s not being able to be activated for what we call filled for delivery to be
able to fuel your cells to promote activity and promote healing okay and
what happens is when you have those B vitamins that are in excess on the
outside and they can’t get through the doorway to get inside eventually those B
vitamins are gonna oxidize okay and basically say oxidize basically it’s
going to be those B vitamins they’re actually gonna drive inflammation
okay those B vitamins are actually and do more harm than good and we’re a lot
of genetic factors are coming and play now is you have this B vitamin in place
and and it can’t get in the cell there are genetic factors with with that
there’s there’s transport genes as well that are pretty kind of advanced genetic
players and deal with what we call you know solar transport carrier genes that
carry certain vitamins and minerals from outside the inside some people have
genetic factors that they’re just genetically weak in some of those
transports they can’t just get the certainty vitamins from outside to
inside and now what happens is all that the vitamin is sticking outside and
eventually it oxidizes it creates inflammation and then the body has to go
to work reduce the net inflammation okay and there’s certain pathways that are
responsible for helping clearing out those free radicals or those oxidize B
vitamins and it’s based our oxidation pathway and where the neuropathy
connection link comes in is nice our nerves need nitric oxide okay it’s kind
of like this is needed cutting evil nitric oxide is needed for vasodilation
of our blood vessels nitric oxide is actually needed for our nerves to talk
to one another okay to be able to say hey I’m doing this today you do this
today let’s kind of regrow let’s fire heal aspire there you need nitric oxide
to enhance that communication aspect now what happens is if you got all this
oxidation these B vitamins eventually what’s going to happen is nitric oxide
levels are going to start ramping up a little bit because there’s nerve damage
going on because it’s oxidation because the B vitamins can’t feed themselves and
then eventually all those oxidized or damaged B vitamins are going to bind to
hydroxide and create even more of inflammation such as proxy knife
right and then the problem there is when people have this chronic inflammatory
you know polyneuropathy diagnosis is they have just massive inflammation and
and we’re a lot of genetic weakness comes is yes it’s sometimes MTHFR and
the finding synthase Metheny synthase reductase that deals with b12 recycling
and and you know capability but a lot of the prom genetically comes into a
weakness and vector of oxide but then weakness and peroxidation in terms of
weakness and s OD weakness and catalase weakness and glutathione peroxidase so
they’ll help control that inflammation and so i always use this example with
patients like a bucket of water okay if you’re taking B vitamins or you can’t
utilize those B vitamins and you’re putting inflammation in that bucket okay
faster than you’re taking it out eventually the water levels gonna rise
and it’s gonna spill over the edge and basically you got a mouse and now all
your body’s doing is trying to clean up the mats if you don’t do things and
start taking water out faster you’re putting in or or take those B vitamins
out faster you’re putting it in you’re never going to recover and so the
genetic connection with this there’s multiple players you know it could be
the inability to transport the B vitamins it could be a once the B
vitamins on the outside and they get damaged the inability to actually clear
out the inflammation process that happens from those B vitamins oxidizing
fast enough so that a bucket of water is filling over the edge okay and so we
look at some of these labs and they’re told that they have a vitamin toxicity
aspect you know their b6 toxicity is a factor or other excess b6 as a factor in
neuropathy or their b12 levels are too high the first thing you should they
should think of is like number one okay are you taking too much of a poor
quality vitamin okay number one and the second part is and most likely what I
see is that there’s problems taken that B vitamin from outside the inside and
you’re actually just driving more inflammation which is they just actually
fuel the fire for the neuropathy in itself where we left off John was you
were what I got from you was you have too much b6 the first thing to think of
is and then you kind then you kind of left me from there so we can kind of
pick up from there and then we’ll edit this video for there yeah so so if you
have lab work and you’re beaten six levels are high so or you have lab work
and your b12 levels are high first thing you should think of is that this is a
problem possibly like I said a couple things number one it could be that
you’re taking garbage vitamins and you can’t process those garbage vitamins
effectively you’re taking a lot of inactive forms of those vitamins and the
second component is is genetic factors that deal with transport from outside to
inside the cell okay and if it’s a transport component where you just can’t
get the vitamins from outside the inside then that’s going to drive inflammation
it’s going to put more stress on for oxidation and eventually what’s going to
happen is you’re gonna start bringing that nitric oxide component in and
driving feeling more inflammation and genetically most of the people that I
see with neuropathy aspects typically fall into this genetic component of
being like a toxic accumulator and that really is a lot of weakness and
glutathione production and recycling is a lot of weakness and proc ‘td
proximation inflammation control so that’s kind of
the first thought process when we’re talking about genetic factors and B
vitamins and if we go further upstream with that yes things like MTHFR plays
into this you know because the thing is is if you have problems will be from a
MTHFR side of things or if you have issues with b12 genes and it’s almost
like you just can’t produce enough biochemical you know or produce enough
active vitamins to be able to kind of methylate and heal and feel the system
make DNA and garne the whole story goes on and on in terms of the vitamins do
you know could be some threes can’t put in a gas in the tank to be able to heal
your heal your body based on the demand based on our environment okay that kind
of leads us to the next thought process with this on these kind of idiopathic
for these chronic inflammatory neuropathy presentations is let’s say
that your B vitamin status is normal you know and let’s say it’s not a oxidize B
vitamin component that’s driving this the next usual suspect goes down to the
epigenetic components and more often than not
people with chronic inflammatory neuropathy presentations or idiopathic
neuropathy I would probably say 70 percent of time it’s going to go back to
heavy metal or chemical accumulation in the body and then that brings in genetic
factors where hey somebody’s a poor detoxifier they’ve got a mouth full of
metal fillings they’ve had led exposure and their body just could not rid the
body of those heavy metals and guess what they’re accumulating those metals
and eventually it’s going to start the whole process with inflammation and
causing nerve damage going for so the it kind of brings back like the foundations
of you know pretty much any chronic health issue that people don’t have
answers to it really comes down to the kind of the marriage between one’s
genetic predisposition okay and so we’re talking on neuropathy were talking about
the vitamin transport we’re talking about inflammation clearance and genetic
factors or somebody’s weak there and then it comes down to the second piece
of that which is the UH pitch of the environment and if if we’re exposed to
things and we can’t get rid of them they eventually gonna catch up with us and
cause damage and heavy metals viruses chemicals they affect the nervous system
pretty darn hard I know we folk Joel when we talk about doing this topic and
I’ve seen many patients with you know idiopathic neuropathy components with
the v6 aspect and pretty much every one of them on top of the v6 excess in the
blood and so there’s a v6 transport issues pretty much every one of them
also had epigenetic component which was a heavy metal tag along and running
metal components it was either something like lead antimony cadmium you know
aluminum and even mercury but lead being the big one that I’ve seen over and over
and over with excess B 6 and those neuropathies yeah listen there’s a
mouthful there John that I’m gonna summarize exactly what you said can so
not to belittle everything you talked about but just sort of put it in more of
a simple or my mind’s a little simpler in terms of number one the first thing
is when you do a test which I think I see all the time and you see all it’s
just because the values are high doesn’t
necessarily mean your your you have a high value of that nutrient I think
that’s a huge distinction in terms of what’s inside the cell what’s outside
the cell number one and unfortunately doctors aren’t really trained at that
when they look at you know a serum test they they don’t really consider that it
could be a low value even though it’s a high value on the outside so that’s
number one number two also like when what we’re putting together is this the
genetic type which is the name of this of this Facebook page in our YouTube
page and basically the business is that there are certain genetic
susceptibilities based on your specific types and you talked about the toxic
accumulator where potentially they’re not good at detoxing because of the way
their genetics are set up and then on top of that if you put in an epigenetic
factor which is typically that perfect storm of a heavy metal a virus Lyme
disease that’s going to cause the bridge from from one side to the other side to
be out so you’re gonna have a lot of overflowing bucket like you talked about
in terms of once that you know nitric oxide level accumulates eventually it’s
spilling over and it becomes uncoupled and then that can create a whole problem
with someone who may be an under stimulator an over stimulator or a weak
immune system which is all the types that we’re going to be talking and
sharing with people but so so as far as maybe talking about let’s say that’s
described someone who’s listening to this oh my gosh I can’t believe it this
is exactly me last yeah I know neural like that’s the other thing that I came
away with is they’re not going to get this information with the traditional
doctors they’re just not there the doctors aren’t looking at the genetic
component they’re not looking at the epigenetic component they’re not running
the right tests they’re not really thinking about fixing this from up
getting to the root cause of the problem it’s just what’s the best medication and
I can put you on and you know just hope that you get out of my office as fast as
you can I hate to sort of put such a gloomy picture on it
as far as what would that person do given like oh my gosh this is me how
would you best recommend what their next steps would be if if this is what you’re
describing right so in you know when you’re talking about chronic
inflammatory neuropathy or Navia passenger op at the aspect you know the
next step is obviously to investigate things a little further because the
thing is that if let’s let’s kind of start with the b-vitamin aspect let’s
say that you go in there and your be 12 volts or high or v6 levels are high and
the doctor is like you gotta stop taking the vitamins and that’s kind of like the
solution to that you know it’s like well that doesn’t really do anything and that
maybe even the wrong suggestion because I can mention you know B and that
something drives me nuts is you know somebody when their physical their b12
levels are high and their doctors like stop takin b12 but you look at a
micronutrient test which looks at the vitamin status inside the cell or you
look at a mess of malonic acid which looks at mitochondrial based b12 and
that person’s deficient you know so it’s it’s not so much that there’s too much
b12 it’s just the b12 can’t get in the cell so it is going to accumulate on the
outside but that person still is deficient inside the cell on that B
vitamin and if they don’t address that they’re never gonna heal okay and
there’s genetic factors that play into that and so kind of investigate things
looking deeper the next step is if you’ve got a if you got a B vitamin
toxicity or you’re told that your your neuropathies driven by B vitamin
toxicity aspects the next thing is two things number one is you want to look at
micro nutrient testing to figure out what’s the status of that vitamin inside
that cell to really determine if you’re toxic because you know yes having too
much outside is gonna drive inflammation but thing is if there’s on the inside
the cell that could be a factor as well and then the next piece of that
obviously you want to look at genetic factors you know you want to you know
investigate this or work with a practitioner that understands genetics
at a level that’s gonna look at these factors it would transport and recycle
these B vitamins because if that’s something that you don’t address you
know your neurological system is just continue to be compromised and
inflammation is just going to continue to do you know spin out of control and
the first thing a lot of times with that is controlling inflammation those
looking at approximation aspects and things of that nature and how your body
can clear and controlling them as those B vitamins are kind of
accumulating outside the cell and driving inflammation the first one the
genetic components you know you’re gonna have a tendency for those B vitamins to
want to accumulate over and over and over again you know something you got to
work lifelong going for and it can be done then the next step is obviously
investigate things outside the box from an epigenetic standpoint you’re gonna go
through the usual suspect if you’re not diabetic it’s not post chemo and I’ve
been taking a statin drug you know you’re gonna want to look at heavy
metals you know first and foremost you know to me that that’s always a starting
point and obviously if there’s other symptoms with the neuropathy that
indicate that okay this person also is Hashimoto’s maybe then you got to look
at viral components you know you know if they’ve got also like chronic fatigue
and other neurological ponents and you want to investigate viruses you know as
well if you want to investigate Lyme component we always gonna want to
address metals because you know very very rarely do I see a patient that’s
got neuropathy when there be even driven by something like diabetes or some along
those lines but the idiopathic or the inflammatory based neuropathy is very
very rarely do I see somebody where we check metals and metals and then you get
into like specifically where these metals specifically disrupt things and
here’s the thing a lot of these metals disrupt peroxidation pathway basically
these metals also disrupt how your body can control inflammation so you kind of
get in this vicious cycle that you’re driving inflammation because the metal
but in the metals it is preventing you from controlling the inflammation and
then that basically just continues to fuel itself and then things get out of
control and you’re left with symptoms that you just really can’t get your
hands around yeah and you know what happens too is they call it the
paradoxical Herc’s iming reaction when they go in there and they try to do a
viral protocol or they do a heavy medical protocol and they just don’t do
well with it because they Clark before the horse I would say they went for a
marathon and they didn’t even pop running shoes right they haven’t even
got there they’re their warm-ups on and there and they’re going ahead and doing
a full-blown marathon which they shouldn’t do so as far as you know I
know when we’ve talked recently that in just your private practice
you just won’t work with anyone that doesn’t have a genetic component because
that’s just looking at the ocean with blinders on you need to see a full
picture but let’s talk about the you know with 23andme and
you’ll still look at those reports because there are value to them but when
we’re deep you know diving deep down into solo transport enzymes and
peroxidation enzymes and nitric oxide enzymes and karach you know all those
things that you’re seeing how many times do you see those coming up incomplete
when you run them through your your system that you’re looking at those
genes that you know you rep you I guess how often do you see that happening
whether just those 23andme and the ancestries aren’t complete enough that
you’re not getting a full picture yeah the thing this is that there’s
limitations in those what they make available to us to download what’s on
their gene cards to give us kind of a full picture you know but the thing is
is you know sometimes like if somebody has that information it can give us you
know oops piece of the puzzle you know so somebody has a version 423 me that
they did you know in 2015 you know it may give us enough information for the
factors that we’re looking at you know it’s not going to give you a lot of the
solo transport carriers that show you B vitamin transport but the thing is is
you know if you have molecular nutrient tests you know or if you have you know
like methylmalonic acid and somebody’s b12 and their blood is high but a
micronutrient test methylmalonic acid is low you know like I don’t need a genetic
test that tell me that okay there’s a problem transport you know so that’s
where kind of just the the the experience kind of comes in from that
side of it but the thing is is you know like we submitted like I what I do is I
specialize in genetics and so for people to work with me I need genetic because
that’s what I do and like I always mention and said there’s many times I’m
not the first doctor to the party you know a lot of people have worked with
you know traditional doctors and work with a lot of alternative doctors and
work with some really good you know functional medicine doctors that have
done a lot of legwork but the genetic components was a big missing piece of
this which allows us to maybe investigating
a little different as well as have some information maybe how to support things
a little different so maybe some of the things are doing properly like doing a
oral chelation protocol for metals you know maybe there is a missing component
of why they’re having bad responses and that missing component our genetic
aspect so you know 23 mean ancestry you know gives us it gives us starting
points if somebody who already has that done but there are more advanced genetic
tests that are out there that we run on our patients that kind of gives us you
know a little bit more the complete picture of somebody that has a chronic
issue specifically something that may have a idiopathic or a chronic
inflammatory neuropathy presentation it’s going to give us more of those
genes that deal with inflammation more those genes that deal with b6 and b12
utilization and absorption and things that nature we can get a clearer picture
of what’s fueling this in the first place because if it’s not the usual
suspects from a genetic standpoint you’re labeled with a idiopathic or
chronic inflammatory neuropathy you know diagnosis usually it comes down
to genetics and what are those epigenetic stressors that have not been
checked or identified yet that are creating that perfect storm and once you
identify in those two pieces now you can get to work on recovery yeah and those
people like you said they’ll never get better I know like personal cases that
just haven’t had the proper workup and they’re not moving the needle whatsoever
and I got to say John what I’m really excited about with you know our project
of your genetic type and doing these Facebook lives is to dispense the
information but we also understand that not everyone can work with you or I
one-on-one but they are very astute and they’re very disciplined and they are
running up against a lot of obstacles with doctors that are are very stubborn
and dogmatic so they put the work into their own hands and that’s our goal is
really need to provide tools for people to a get the test right so that they can
confirm that I have the test and then B get the follow along information so they
may not necessarily be working with URI directly but they can also have a cheat
sheet if you will or a user Gide to be able to you know a understand
their genetic type I mean we’ll talk more about that and you know as we go
forward on the Facebook lives but realize hey you probably have a genetic
type number one that makes the perfect storm that much more perfect for
expressing expression and we want you to understand that first we don’t want you
to have to go and and you know relearn methylation we just want to sort of give
you the cheat sheets and understand what’s your genetic type first and then
from there what are the proper tests based on that genetic type so that you
can get the most value from it and and understand how to interpret them and
then most importantly understand how to implement the information that you have
so maybe talk just a little bit about that as a teaser to give the you know
people that are listening what that entails yeah so you know when we talk
about like you know the previous image of our crash course that we did you know
and even you know patients or people I spoke with that are trying to learn
genetics a lot of it’s you know you know sometimes can get too advanced and so
we’re really kind of done it’s trying to streamline this a little bit where based
on you know history and based on genetic factors you know people can really real
quickly determine what their genetic type is and then based on that put their
focus on that genetic type and and then based on that based on symptoms based on
the genetic type then be able to kind of determine what are the rabbit holes that
they have to go down to investigate you know what are the usual suspects that we
see in our office that we would recommend to a patient sitting in front
of us that has a neuropathy presentation and this is their genetic predisposition
going into it one of the things that we would look at you know and so we’re kind
of putting together like you said kind of a user’s guide you know kind of an
algorithm so people can say all right they can go from point A to point B to
Point C and do some of the stuff on their own and be able to take that stuff
back to their doctor you know we needed to be able to really kind of take their
health back into their own hands to get resolution you know because it’s all
about improving quality of life and you know I’ve seen many many people with
neuropathies and it’s not it’s not fun you know and you’re relieved
effect quality life and affects sleep it affects ability to you know be active
you know from a pain standpoint it’s just miserable and so if somebody can
understand that okay there are these genetic factors and based on things that
we’re putting together that people are gonna be able to learn about and it’ll
kind of classify that they’re very specific genetic type but their focus
genetically there and then be able to investigate these usual suspect
stressors and then these are the things you can do to address that and with that
people can start getting on control and getting quality of life back and that’s
what this is all about yeah and you know really get some significant improvement
it’s because they’re not dumb I mean they’re doing a lot of great work
already the majority of the people that are already on their radar but it’s that
extra two degrees that they need to turn the temperature up to sort of bring it
to a boil and really see those improvements and I always say it’s sort
of good news bad news I mean the bad news is when you have a neuropathy or
you have a methylation issue or you have a perfect storm of the environmental
factors that you have that just super overlap with the genetic
susceptibilities a lot of things are off right not just peripheral neuropathies
but central neuropathy is like brain fog focus concentration which that can be
even more debilitating than someone that doesn’t feel their hands or their toes
and then and then from there really understand what the genetic component is
and what the proper test to confirm it is and then really it’s a matter of
implementing it and having the buckets drain and seeing that extra temperature
turn up so that now they’re seeing amazing improvements and all the things
that weren’t working from the perfect storm are now working and you can you
have the tools to have it be like a verb and now it’s not just a one-time thing
and now you get to understand like what are like you said to me John like I
think you said it’s well like everyone’s gonna like explain it everyone’s gonna
have like you know even even you and I are gonna have you know stressed moments
or a reactivation of a cold or a flu but now they’re equipped with how to do what
to do with it so kind of sum that up in a nutshell like what
mean yeah so the thing is like when you’re talking about genetics and in you
know we talked about the expression of these genes and how our environment can
express these things because a lot of times you have these genes your whole
life obviously and they’ve never been a player and so a lot of times once
they’re expressive and dimmer switch you may not be able to turn it off but you
can dim it down but if there’s things you do it’s maybe going to turn that
dimmer switch back up and so symptoms may ramp up and so what I always tell
patients and people I talked with they have chronic issues is you know once you
kind of determine that that that kind of marriage between your genetics your
epigenetics right and you figure out how to kind of really manage those two
stories or you’re trending in the right direction you’re healing your your
recovery you know it’s about quality of life and and I always tell patients this
it’s it’s if you can have you know 26 or 27 good days out of a month but there’s
a couple days that are just not so good that’s a that’s a win you know and more
importantly one of the things you can do that when you do have a bad day you have
strategies to pull yourself out so that the bad day doesn’t hurt here into about
a week and doesn’t that month you’re able to recover and bounce back and like
I told you you know when we talked I think it was earlier this week that you
know hey you know everything we do we still have bad days you know those days
that I don’t feel great you know it’s like but it’s things you can do to
recover to pull yourself out within a couple of hours or by the next day so
that hey you’re right back where you need to be and we’re human and the world
we live in you know we’re supposed to chemicals were exposed to toxins we’re
supposed to you know bacteria and parasites on our food that our body our
Muse ISM is gonna try and fight off and so you know there’s gonna be days it
just aren’t that good but if we if our body is able to bounce back real quick
how it’s supposed to that’s what this is all about and that’s what we really
strive for him so you know realize that if you’ve got neuropathy symptoms you
know what this talk is about but it really kind of plays into any you know
chronic health issue that if things have turned in the right direction
and hey you get to the point where quality lives better and things are real
stable but you have a couple days here or there where you notice symptoms
ramped up again it just it’s part of the process it’s part of being human okay
but you know it’s more like I said it’s about that change is
about quality live and it’s about that information you don’t take that into
your hands to kind of understand that and that’s so empowering yeah especially
like as we’ve categorized to John as you start to learn finally your genetic type
like it makes so much more sense like oh my genetic type is I’ve always had you
know weak immune system where I get overstimulated so you know that’s coming
really soon guys so we’re saying within the next week or so not even they’re
going to be less than two weeks from yesterday if that’s the goal right
exactly less than two weeks from yesterday just really rolling out our
foundational genetic type program so that you can start to whet your palate
and start to understand what you can do about this so that’s super excited also
you know make sure that you you let you know you follow us on YouTube we’re
gonna have your genetic type videos we’re gonna have also podcasting we’re
gonna also be doing you know our genetic type website where you’re going to be
able to get access to all of this stuff so also make sure that you post you know
any comments in the thread the only problem about zoom is you don’t see live
thread comment so John and we’ll go back in there and answer them and if you have
any questions that you want for us to cover on a topic for a Facebook live or
a podcast those are how that’s how we got this conversation today and usually
when one person asks a question a thousand people have the same question
so we really value your input to give us some you know what you guys want to hear
I’m John anything else you want to add no I think we kind of you know covered
what we intended to cover with this and hopefully you know it probably you know
you know created some more questions and some answers but at least they you know
there’s some answers to think outside the box and start you know trying to get
control of this and more importantly realize that there are answers out there
you know there are answers that are stressors from an epigenetic standpoint
there are answers from a genetic standpoint and drive this in the first
place and now you just got to get to work and figure out those pieces of the
puzzle and with that more often than not you’re going to be able to get control
of this yeah I noticed I mean you know a lot you and I owe a lot of
recognition for you know the Trailblazers and dr. Lynch for getting
you know MTHFR on the math but notice we really never even talked about MTHFR
into a tunic to a largest extent and that’s what we want to do is whatever
paradigm shift we’re MTHFR is super important and it
did start to open that door but now how do we use it in terms of what’s going on
with me and what I’m dealing with and John and I have had private practices
for a long time now where we’ve gone through the you know trial and errors of
how do we organize this so that we use the information so you the end user
don’t have to be the scientists or the doctor and you can just implement your
genetic type so that you get the best results going forward so super excited
John I’m glad we did this today we’ll do another one every Tuesday at 3 p.m.
Eastern Standard Time and and then look for the next two weeks to start to
understand about your genetic type and that’s that’s what we got for today

4 Replies to “MTHFR, B Vitamin Toxicity and Neuropathy”

  1. Thank you so much for talking about this. Currently dealing with everything described here. All the doctors I've seen
    don't seem to care about genetic factors. It wasn't until recently that my Neuro noted that i had the MTHFR mutation and that maybe my symptoms had to do with excessive B6 accumulation. Test came back with 82 ng B6! Finally, a test came back that pointed towards something more going on. I don't have a lot of places to turn for answers, so this is extremely helpful.

  2. Happy to see someone putting out content on this. I have struggled fo years with intense hot burning and crippling fatigue, nausea, fog, and more. Once it got completely debilitating, they discovered it was B6 toxicity. NO explanation as to how or why this was happening to me (I don't take it as supplement or drink energy drinks). I was prescribed ALA and it has helped a lot, but I don't understand what is causing it. I requested the MTHFR test, and was told it wouldn't be a factor. 4 Doctors told me they had never seen this before, and to just take the ALA forever to manage.

  3. My lab work came back with abnormally high B6 , doctor told me to stop taking my daily vitamin , I told her I don’t take a vitamin , I came to realize my melatonin that I’ve been taking for over a year has B6 added so beware if lab results show higher almost toxic levels of B6 to get off that particular type of melatonin with added B6

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