The Deadliest Being on Planet Earth – The Bacteriophage

The Deadliest Being on Planet Earth – The Bacteriophage

[Music] A war has been raging for billions of years, killing trillions every single day, while we don’t even notice. The war is fought by the single deadliest entity on our planet: the bacteriophage or ‘phage’ for short. [Intro + Music] A phage is a virus; not quite alive, not quite dead. Also, they look as if someone made them up. Their head is an icosahedron, a sort of dice with 20 faces and 30 edges. It contains the genetic material of the virus and often sits on a long tail that has leg-like fibers. There are more phages on earth than every other organism combined, including bacteria. And they are probably everywhere living things exist. Billions are on your hands, in your intestines and your eyelids right now. Which might make you nervous since phages are responsible for the majority of deaths on earth but you’re lucky. While they do commit genocide for breakfast, they only kill bacteria. Up to 40% of all bacteria in the oceans are killed by them every single day. But phages also have major flaws. Like any other virus, phages need a host to survive and reproduce. They’re not much more than genetic material in a hull and they specialize. Usually, a phage has chosen one specific bacteria and maybe some of its very close relatives. These are its prey. Imagine a phage as like a cruise missile that only hunts and kills members of one very unlucky family. When a phage finds its victim, it connects its tail fibers with receptors and uses a sort of syringe to puncture a surface. In a weird motion, the phage squeezes its tail and injects its genetic information. Within minutes, the bacteria is taken over. It’s now forced to manufacture all the parts of new phages. They only stop when the bacteria is filled up with brand-new phages. In the final step, they produce ‘endolysin’, a powerful enzyme that punches a hole in the bacteria. The pressure is so high that the bacteria sort of vomits out all of its insides and dies. New phages are released and begin the cycle anew. In the last few years, bacteriophages have enjoyed the attention of the second deadliest beings on earth: humans. Recently, we’ve started looking into injecting millions of them into our bodies because we’re sort of getting desperate; we screwed up. In the past a single cut or a sip from the wrong puddle could kill you. Bacteria were our phages. Tiny monsters that hunted us mercilessly. But then, about 100 years ago, we found a solution in nature. By accident, we found fungi that produced compounds that killed bacteria: antibiotics. Suddenly, we had a powerful super weapon. Antibiotics were so effective that we stopped thinking of bacteria as monsters. Only the old and the weakest among us were killed by them. We used antibiotics more and more for less and less serious causes. We lost respect for the monsters and the weapon But bacteria are living things that evolve and one by one they started to become immune against our weapons. This continued until we had created what are called ‘superbugs’, bacteria immune to almost everything we have. This immunity is spreading across the world as we speak. By 2050, superbugs could kill more humans a year than cancer. The days when a cut or bladder infection or a cough could kill you or your loved ones are coming back. In the US alone, more than 23,000 people die from resistant bacteria each year. But it turns out that phages, our tiny killer virus robots, could save us. We can inject them into our bodies to help cure infections. Hold on, how could injecting millions of viruses into an infection be a good idea? Phages are very very specialized killers of bacteria. So specialized, in fact, that humans are completely immune to them; we are too different. We encounter billions of phages every day and we just politely ignore each other. Antibiotics are like carpet bombing, killing everything even the good bacteria in our intestines that we don’t want to harm Phages are like guided missiles that only attack what they’re supposed to Wait a minute, if we use phages to kill bacteria, won’t bacteria develop ways of defending themselves? Well, it’s more complex than that; phages evolved too. There has been an arms race between them and bacteria for billions of years and so far, they’re doing great. This makes phages smart weapons that are constantly getting better at killing. But even if bacteria were to become immune against our phage, we still might be able to win. It turns out that in order to become resistant to even just a few species of phages, bacteria have to give up their resistance to antibiotics. We might be able to trap them in a catch-22. This has already been successfully tested with a patient who had no other hope left The bacteria ‘Pseudomonas Aeruginosa’, one of the most feared bacteria, infected the man’s chest cavity. They are naturally resistant to most antibiotics and can even survive an alcoholic hand gel. After years of suffering, a few thousand phages were directly inserted into his chest cavity together with antibiotics the bacteria were immune to. After a few weeks, the infections had completely disappeared. Unfortunately, this treatment is still experimental and pharma companies are still reluctant to invest the necessary billions in a treatment that has no official approval yet. But things are finally changing. In 2016, the largest phage clinical trial to date began and phages are getting more and more attention. and we better get used to it because the era in which antibiotics have been our super weapon is drawing to a close. It might be a weird concept but injecting the deadliest being on planet Earth directly into our bodies could save millions of lives This video was made possible by a grant from the Bill & Melinda Gates Foundation If you’d like to support Kurzgesagt, you can do so on and get fancy things in return.

100 Replies to “The Deadliest Being on Planet Earth – The Bacteriophage”

  1. Giving antibiotics to live stock has had 100 times more impact on resistance then over prescription of the same drugs.

  2. Good day! I would like to ask, if the bacteriophage overpowered certain bad bacteria then grew into millions of population then how do they die or be destroyed? I mean if they have nothing left to eat or to replicate with will they destroy themselves or what?

  3. That's all fun and good, but what happens when the phages evolve to kill humans as well? It's not likely but it still could happen.

  4. ok now seriously if school teaches us like these videos, i wouldnt bother thinking about school, it will be like watching a movie

  5. So basically all we meed to know is if Phages only evolve for specific bacteria, and not radically mutate and start targeting Human cells? If so, then this thing is the even-generation savior, and the odd-gen would be plain ol' antibiotics.

    I wanna know opinions. Share them and let's discuss. I'm talking to everyone that sees this ambitious comment.

  6. Talks about how superbugs will kill more people in 2050 than cancer
    Me: Ahh hell no!
    Talks about how phages will save us
    Me: Ahh hell yeah!

  7. So people are stupid and have brought superbugs upon us all, and now we will have to inject the deadliest thing in the world into us to stop it… yeah humanity this is why aliens wont take us seriously

  8. What if viruses start evolving themselves to target human cells? Well HIV is pretty famous virus which does affect humans…

  9. Of course Big Pharma isn't going to pick up something that is actively going to treat and/or cure most medical issues. They thrive off of us being sick. If we make something that cures us, they lose money and may eventually go bankrupt.

  10. Hold on, what about phages that are specialized to kill bacteria which are good for our body? Wouldn't they be dangerous?

  11. phages can't effect or target humans, but viruses that effect humans can, and both are particularly good at horizontal gene transfer

  12. Bacteria: goteem

    Humans: reverse card

    Bacteria: evolves and reverse reverse card goteem again. Sorry kid but you’re finishe—

    Humans: reverse reverse reverse card and phages

    Bacteria: N-NANI?

  13. The deadliest bacteria is people
    Because if we not throwing a garbage on the sea or something on nature bacteria has a new species

  14. Humans: * has cancer *

    CANCER:hahahahahaha you are dead know,wait what is this thing
    Cancer: * touches phage *
    Phage:How dare you oppose me Mortal!!
    Human:What is happening right now I hope the phages work

  15. 4:43 omg i loved that game as a kid.
    we used to play with friends all the time. good times.
    i love this channel. it's interesting*and* fun

    dammit guys right in the feels

  16. So just like that we've found a plausible answer to superbugs or Rhino viruses like the Flu? Neat.
    We really needed this extra help against microbes because we can migrate and spread them with us faster then even birds probably.

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