The Revolution in cancer treatment has begun. Targeted therapies and the Oncofocus DNA Cancer Test

The Revolution in cancer treatment has begun. Targeted therapies and the Oncofocus DNA Cancer Test

Cancer is a very difficult disease. Cancer in many ways is part of life Cancers have a very independent biology and grow uncontrolled And that’s essentially the problem, that we have cancers that have an uncontrolled grow pattern There are tumours that can spread to other areas of the body and eventually become resistant to the standard conventional treatments we have available to us Obviously it’s a very frightening time for a patient who has been diagnosed with cancer and it’s all a new experience for them and their families, and a very worrying time so, obviously the first question to answer is “is it terminal?” “can it be treated?”, “what are the treatments that are available?”, “are they successful?” Chemotherapy has been around for a long time Chemotherapy has been around since the 1950s chemotherapy was first discovered as an accident with the use of mustard gas as a poison in the second world war and it was recognized that it led to low blood counts in many of the service men, the soldiers and that was used then as a potential treatment for childhood leukemias, for limphomas the problem with conventional treatments, conventional chemotherapy treatments is that these treatments are not specific, so they effect normal cells as much as tumour cells because chemotherapy targets proliferating cells So, the problem with chemotherapy is that there is no specificity So, one of the big areas of development of the last two decades has been the development of what are called targeted therapies As I get older and as I practice longer I’m less and less prepared to accept toxicity for may patients As I have been doing this job over the years I’m less inclined to deliver very intensive treatments unless I really see a major benefit and the truth is that chemotherapy doesn’t always offer major benefit what we have realized in the last two decades or so is that these tumours are actually all the same in some way they are driven by the same type of oncogenes or tumour suppressor genes these various cancer genes are actually common in all the histological types so rather than focus on the histological type what we do now is to focus on defining the tumours by virtue of mutation more and more patients are becoming aware of targeted therapies that are out there and I suppose maybe going back to Herceptin in breast cancer and the success rate we have had with that patients are very much aware of that. Patients nowadays are very much educated on medical issues There are around 580 targeted therapies available today, including drug combinations the problem today has been that there hasn’t been a test that was able to link those targeted therapies to individual patients The advantage of this approach is that is much more comprehensive analysis of the tumour and I have no doubt that in twelve months this will be the standard of care There are a few precision oncology tests out there in the market the majority of them have been developed as research tools so they are normally used to link patients for enrollment into clinical trials so they are not based on “clinical evidence” where what is defined by that is approval of the therapy by the worldwide regulators so the FDA and the EMA. We also include guideline references issued by ESMO and NCCN in the US and also all those therapies that are currently in clinical trials Now, these are all controlled clinical trials that are under the umbrella of the FDA So this is the minimum evidence that we require to be able to link a mutation to a target The key difference with the Oncofocus Test is -there are a number of differences- to me the key difference is its breadth in other words the extend of mutations that we look for have also incorporated a specific test called Immunofocus which looks at the PD-1 assay which is a very important part of targeted therapies in the future So the difference with theis analysis is that we get not only a very broad range of mutations identified but they are specifically linked to available targeted therapies I got involved by Prof Williams and Dr Loddo two to three years ago when they founded the company they approached me in relation to supporting them on the commercial side because of my nursing background and my legal side and I am amazed and enthralled every day by the passion they bring to driving the Oncofocus Test forward This is not research, we do not include any research data, any research publication competitors tests out there would link the supported association between the mutation and the drug based on research paper or a small academic study or a case study we do not include any of them. Our test is entirely based on clinical evidence generated either as part of controlled clinical trials, the very minimum all the way up to real approval of therapies and licences given by the regulators as my history in nursing, if I can anyway contribute to that sort of change then… I’ve achieved what I really wanted to achieve when I first entered into nursing and then moved onto law and that for me is just a groundbreaking work, and I am privileged to be involved

3 Replies to “The Revolution in cancer treatment has begun. Targeted therapies and the Oncofocus DNA Cancer Test”

  1. I’m interested in this – so many advances in cancer and targeted therapy is the way to go – chemo can work to suppress but not cure

  2. I have nothing to lose by knowing more about OncoLogica. It makes sense to look at alternative therapies when chemo has, in my case, been exhausted.

  3. There are numerous plant extracts that we have described to Cancer sufferers and they have then chosen to included some of these natural compounds in their diet of their own free will after conducting their own research. We do not prescribe anything to anyone. Many of the individuals have managed to reverse their tumour growth until their Consultant or GP found out and instructed them to stop taking any dietary supplements they were not taking BEFORE they were diagnosed with Cancer and began conventional treatment. The egotistical 'Doctors' believe they know best and they are afraid that the patient might recover without conventional treatment – or rather in spite of it! All Cancers are unique to the specific individual – that is why there will never be ONE cure for Cancer. Each person's DNA and immune system will respond differently to the next person – even if they suffer from the same type of Cancer. And forget the Warburg approach – it is bogus. The human immune system is the best weapon against Cancer – but it needs to be stimulated and strengthened to such a high level that only certain phytonutrients have the potential to achieve a positive effect and reverse or shrink Cancer tumours. It is impossible to predict with any certainty which single or combination of individual phytonutrients and at what level will work best with any unique Cancer patient. There is no 100% cure for everyone and there never will be. The Cancer money train continues to plunder billions of pounds/dollars from our society, that's just the way it is, nothing will ever change.

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