Using Viruses to Fight Antibiotic-Resistant Infections

Using Viruses to Fight Antibiotic-Resistant Infections

– Bacteriophages are the most numerous replicating entity on the planet. (ethereal music) There are more phages than
there are stars in the universe. Every drop of sea water has 10
million bacteriophages in it. Bacteriophages are viruses, basically pathogens of a pathogen. We’re at a point in time now where the antibiotics that
we’ve used for decades have increasingly become less effective at treating infections. If there is a tool that we could use that could help someone, then of course we should
try and pursue it. (ethereal music) (printer printing) – You guys have a merry Christmas. – Cystic fibrosis is
what you would refer to as an invisible disease because on the outside
I look completely fine, but that doesn’t mean that’s
how it is on the inside. (ethereal music) Cystic fibrosis basically covers the entire inside of my body in mucous. That makes it where it
messes up the lungs, the pancreas, the liver,
pretty much everything. Yeah, I feel so tired I can’t function. I’m like ugh. – Are you like, um, are you feeling achy? Or is it just this overall… – Just tired and coughing. – Okay, alright, sweetheart, we’re gonna have you come
over here to do the lung test. (patient coughing) – If you’re ready. Blow, blow, blow, blow,
blow, blow, blow, blow, blow. Deep breath in. (patient coughing) – 69 percent. – Mkay, alright. – The higher your lung function is, the better your life expectancy is. And actually on the paper, it will say like this is the
lung health of a 67 year old. So I’m 22, but it shows
on there 67 years old. I wanna be a mom one day. To think maybe one day
I could go nine months without being on all these antibiotics. Then I would have nine months where my baby could grow in a normal body. My best case scenario for phages is to at least get my
lung function to 85 to 90. I would be so happy. (ethereal music) – Okay, so here’s my fridge
full of all my water samples and some phages from all over the world, places I’ve visited to sample. This is sewage from a town in
Mexico called Cuatro Ciénegas. From here there’s a pig
farm, here in Connecticut. These are from Uganda and Kenya. I have phages that we
used for Paige here. – So New Haven, Lyme, Connecticut and one from East Africa,
from in the Congo. (machine shaking) – Boom. – So as you can see in
the tube here on the left, it’s Paige’s bacteria alone, okay. And then the one on the right is Paige’s bacteria plus bacteriophage. And you can see it’s
really turbid here, or cloudy, this means the bacteria are growing. And in this tube here it’s very clear, which means the phages killed the bacteria. So from here, all we gotta
do is clean up the prep, concentrate the phages and then
we can ship it off to Paige. (ethereal music) – On a daily basis I spend probably about four hours just maintaining my health. – Thirty minutes.
It’s on the highest setting right now, and even though it works, it
still just doesn’t get everything. (vibrating) – I have not been
informed, about anything. – Yeah, like, I’m excited
for the phages ’cause I just really feel like they’re
gonna work for sure. But I’m really nervous as well
because it’s my last option. Yeah, ’cause antibiotics
don’t work at all anymore. So I really need these to work. (plane engine turning off) – Little bit nervous but
I think I’m prepared. I hope I’m prepared. We’re at the Dallas airport right now, and we’re about to catch
a flight to Lubbock, Texas so we can treat, um, Paige. (flight attendant speaking over intercom) Tomorrow morning I’m
most looking forward to meeting Paige actually,
and then obviously, getting past the treatment, um. It’s really just gonna be super simple. (slow guitar music) – About three years ago, it was
time to treat the Pseudomonas and I did a two week round of the antibiotics and it didn’t work. (suspenseful music) My lung function didn’t go up from it, and my pseudomonas didn’t go away. I couldn’t even do things
like take a shower by myself. Whenever I lifted my
arms up to wash my hair, I couldn’t breathe, I would
feel like I wanted to cry. I needed help with absolutely everything. (dramatic music) To think that without the phages, that could be my normal
life is extremely scary. – We’re uh, fixin to do phages for Paige, for the first time. Since Dr. Kanu actually
set everything in motion I guess it’s only been seven months but, it seems a lot younger, so yeah. It’s been a long time coming. (ethereal music) – So we just want to make
sure that you are aware this is experimental, it’s not a proven scientific thing, okay? – This could be a game
changer for Paige, ya know? This could be the key to
her living a normal life. Having children. Uh, going on to do the things that, you know, she’s always wanted to do. She could go far, but this
disease has held her back. – I discovered phages actually by hearing about it from my dad. – Mr. Rogers brought this up to me and, after finding several
articles on bacteriophage, I was able to share this
information with Dr. Chan, which he very quickly came up with a cocktail of bacteriophage for her. – Okay.
– Okay. – We doing this? Alright, lay down. – I don’t know if it
will all fit in there. – 10 mls. (machine whirring) (ethereal music) – It’s a little terrifying
to think that like, something that I made was
going to be used as a medication. It’s not like it was made somewhere else and I was just delivering
it, like, I made that. – I feel really excited especially since it’s almost done and there aren’t any side
effects that have gone wrong. – I have to miss out on
a lot as it is, you know. But this–there’s times you just
gotta be there, you know. This is definitely one of them. (ethereal music) – It still doesn’t feel real. I’m hoping in five years
I can look back at this and be like, oh, wasn’t that crazy that was my last option
and look at me now, with lung function in the
90’s, living life normally. (soft piano keys) (birds chirping) – Anyone who knows me
knows I like my makeup. I get up, I put my makeup on
even if I’m not going anywhere. I literally, in February, went two weeks without putting on makeup,
laying on the couch in my pajamas. So I felt like, man, I don’t
know if this is working. But March came and I was like, wow. I thought, uh, it’s making me worse. But no, it’s definitely making me better. (deep breath) – Blow, blow, blow, blow,
blow, blow, blow, blow, blow. Deep breath in. (coughing) – The air in one second was 79% so, we would call this stable. – My lung function really
isn’t that much better, yet it feels so much different. (talking and laughing) (gun shots) – Whoo! – You know, within ten
days after we started giving her bacteriophages
to treat her lung infection, we found that the bacteria
that was growing in her lungs had reverted to being
drug sensitive again. – I needed the phages to make me where I wasn’t antibiotic resistant anymore. Now that I can use the IV’s, I use that to get rid of the pseudomonas. Whenever Dr. Kanu first
showed me how sensitive my pseudomonas was to
all these antibiotics, I didn’t care who I was
around, I just started bawling. – Well she’s got a lot more energy. You see her wanting to do things. You can just tell she feels better. – You can bend a little bit. – Before if all I could do was lay on the couch and stay inside, how could I get a good job,
how could I be a mother? But now there’s hope,
because I have energy. Casey even said that
he can see a difference in my quality of life
and how I’ve been acting. He loves it when I go to
the gun range with him, but I never would, so he’s been excited, because we’re able to
do more together now. – When she volunteered for
this treatment it was huge for the CF community,
the scientific community, and there’s a lot of
people that could really benefit, I think, from
the results of this. – To be completely honest, I had no idea what the phages were going to do. But now there’s times I
think about it at night and I still just cry, ’cause I’m so happy. Like, to think, okay we
got this under control. Like, life’s good. (gun shot) – I don’t like your gun. – Huh? – I don’t like your gun.

31 Replies to “Using Viruses to Fight Antibiotic-Resistant Infections”

  1. I remember Kurzgesagt did a video on phages but I like yours so much better!
    Everyone in this video also seemed like such genuine people; thanks for sharing!

  2. It's a natural human instinct to go for the biggest guns first, but that's not a wise way to go about things. Start with 22's; they're easier to handle (and the ammo is a lot cheaper and lighter, so you can fire more of it more easily).
    …Oh, and I'm glad to hear the pseudomonas is being treated.

  3. This awesome. Excited to start seeing this treatment option used in the future. Although, I wonder if the delivery options will change from mist to pill form. Perhaps injections, or nasal sprays as well. I guess it will depend on the pathogen.

  4. Some of virus is vaccine-resistance but more virus become vaccine-resistance so it also affect others medicine as well (sadly))

  5. Research colloidal silver, its experimental but their have been multiple studies ranging from it being a possible cure for breast cancer to killing ebola.

  6. We are seeing the catastrophic effects of antibiotic resistance worldwide. This video highlights the importance of alternative less costly medication therapies. I hope the application of bacteriophage may be broader in future. New subbie!

  7. Stupid video ! Looks smart because you are not informed. In fact is BS.
    Get MMS and you don't need any antibiotic, at all.
    Make cl O2 and you can kill ALL bad bacteria , viruses and most fungi.
    Don't believe medical drs ! Their life expectancy is just 58 . They cannot help themselves .

  8. With embryonic stem cells from aborted babies they made cells that are resistant to antibiotics so I am highly suspicious of what they claim.

  9. Cystic Fibrosis= Biofilm? NAC, lung anti-microbials, alpha lipoic acid, moringa, capryllic acid and glycerol trinitrate (could be spelling it wrong), untreated Sinus infection? possibly Staphylococcus with other infections? Holistic Medical Doctor? Glad they're using them in the US again, love the Dad researched wish all parents would, and kudos for Dr. Chan etc

  10. Bacteria allegedly cannot defend against Bacteriaphages and Antibiotics at the same time? Though I wonder if a fungal candida hyphal infection or other pathogen could be treated?

  11. It's things like this why I went into biomedical engineering, and I would love to sit down and talk with some of the people involved with this channel.

  12. How would someone get into the testing stage? I am not too far from UCLA. I have Staphylococcus aureus that is consistently causing me frontal sinus infections, bronchitis and pneumonia in a short time if I do not constantly get various antibiotics, and I suspect that someone close to me is probably a carrier, where I get the infection, she has a constant cough that never completely goes away. Currently I have been suffering from COPD in addition to this, and feel tired most of the time.

    Is there any trials, or is my only hope either creating my own trials or see if I can possibly get enough money to get treatment in Republic of Georgia? Even though I am currently disabled for this and a few other causes. I can be reached by e-mail.

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